What is MTHFR?
MTHFR stands for methylenetetrahydrofolate reductase, a collection of genetic mutations that can make it harder for your body to absorb and use B vitamins. MTHFR mutation is a gene variant that affects the body’s ability to process homocysteine, an amino acid that can cause low vitamin B levels and high levels of homocysteine in the blood which can be a precursor to migraines, chronic pain/fatigue, recurrent miscarriages (birth abnormalities) , neurological conditions, dementia, heart disease depression, anxiety, and some cancers. (1,2)
To test for MTHFR mutation, a person can undergo genetic testing, which involves providing a blood or saliva sample for analysis. (2). The test can reveal if a person has one or two copies of the mutation, and which type of mutation they have (C677T or A1298C) (2).
Treatment for MTHFR mutation depends on the type and severity of the mutation, as well as the symptoms and health issues a person may have. Some possible treatment options include:
- Taking supplements of folate, vitamin B12, vitamin B6, and other nutrients that can help lower homocysteine levels and support methylation (2,3).
- Avoiding foods that are high in synthetic folic acid, such as fortified cereals, breads, and pastas, as they may interfere with the body’s ability to use natural folate (2,3).
- Eating foods that are rich in natural folate, such as leafy greens, beans, lentils, nuts, seeds, eggs, and liver (2,3).
- Managing other risk factors for cardiovascular diseases, such as high blood pressure, high cholesterol, smoking, and obesity (3).
- Consulting with a doctor or a genetic counselor about the possible implications of MTHFR mutation for pregnancy, as it may increase the risk of neural tube defects and other complications (2,3).
Along with a B vitamin supplement, supporting your body with regular exercise and an anti-inflammatory diet will help lower homocysteine naturally to protect your health long-term.
Many people with MTHFR are also deficient in magnesium (and require more of it than a person without the mutation).
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